The global radiation proctitis treatment market is expected to progress at a healthy CAGR of around 7% from 2021 to 2031. Demand for acute radiation proctitis treatment is high, while over the coming years, the need for chronic radiation proctitis treatment is expected to increase significantly.
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Cost is one of the major factors that influences the selection of treatment. Hyperbaric oxygen therapy is one of the few treatments for patients with severe radiation-induced symptoms, which include proctitis and cystitis with bleeding.
Currently, hyperbaric oxygen therapy is expensive, and therefore, low- and middle-income patients are unable to afford it, despite significant therapeutic effects. This might act as a major restraint for the growth of the radiation proctitis treatment sector.
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Although treatment for acute radiation proctitis remained dominant, attributed to a high prevalence rate (20%), chronic radiation proctitis treatment is anticipated to witness significant momentum in the forthcoming decade. While acute side effects manifest up to 3 months post treatment, chronic ones usually occur 3-6 months, or even years later post radiation therapy.
Medical therapy involving use of high amifostine and sucralfate has proven to be quite effective in imparting a protective barrier against the early and late short-term effects of radiation therapy. Moreover, research has concluded that use of synbiotics and microbiotics can be used to manipulate intestinal flora to prevent and treat CRP. Sun Pharmaceutical Industries is amongst the leading manufacturers of amifostine drug candidates.
By treatment, oral radiation proctitis therapy is expected to remain dominant, attributed to its non-invasive nature. Amongst all oral treatment option, anti-inflammatory drugs consumption is expected to be the most widespread. Sulfasalazine, balsalazide and mesalazine are some important anti-inflammatory drugs deployed to treat radiation proctitis.
A number of regional level manufacturers offering anti-inflammatory treatment. These include Valens Molecules (sulphasalazine), PharmaZell (balsalazide), Surya Life Sciences (mesalazine), Jiangsu RUIKE (sulphasalazine), Corden Pharma (sulphasalazine) and BEC Chemicals (mesalazine) to name a few. These ingredients prove highly effective in scavenging oxygen radicals and inhibition of bacterial flora.
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